Prices checked October 24, 2026. All amounts in US dollars.

How much do GLP-1 medications cost without insurance in the US?

Short answer: list prices are over $1,000 a month, but the manufacturers sell directly to cash-paying patients for much less: about $199 to $499 a month for Ozempic and Wegovy pens, and $299 to $449 for Zepbound if you keep refilling on time. A prescription is always required.

List price vs. self-pay price (October 2026)

Medication (maker)	Form	Self-pay price per month	List price per month
Ozempic (Novo Nordisk)	weekly pen	$199 for 0.25 and 0.5 mg (first two fills for new patients, through Dec 31, 2026), then $349 for 0.25–1 mg; $499 for 2 mg	$1,027.51
Wegovy (Novo Nordisk)	weekly pen	$199 for 0.25 and 0.5 mg (first two fills for new patients, through Dec 31, 2026), then $349 for 0.25–2.4 mg; $399 for 7.2 mg	$1,349.02
Wegovy pill (Novo Nordisk)	daily tablet	$149 (1.5 mg), $199 (4 mg), $299 (9 and 25 mg)	—
Zepbound (Eli Lilly)	weekly, via LillyDirect	$299 (2.5 mg), $399 (5 mg), $449 (7.5–15 mg) if refilled within 45 days; otherwise $499 (7.5 mg) or $699 (10–15 mg)	about $1,087
Mounjaro (Eli Lilly)	weekly pen	$499, all doses	$1,112.16

Self-pay prices from NovoCare and LillyDirect, list prices from GLP1Numbers' October 10, 2026 table. All prices in US dollars, with a valid prescription.

Where the self-pay prices come from

NovoCare Pharmacy (Novo Nordisk) for Ozempic and Wegovy, delivered or picked up.
LillyDirect (Eli Lilly) for Zepbound and Mounjaro, delivered or picked up at participating pharmacies.
TrumpRx.gov, a federal site launched in February 2026, lists the same GLP-1 prices and sends you to the manufacturer or a pharmacy coupon. It is not a lower price tier.

Novo Nordisk has also announced lower US list prices for Ozempic and Wegovy starting January 1, 2027. That mainly matters to people on high-deductible or coinsurance plans whose cost is tied to list price.

Monthly cost calculator

Price per pen, box or fill (US$) Doses per pen or fill Insurance or savings card pays (US$ per fill) How often you take a dose (as prescribed)

This only does arithmetic on the numbers you enter. It doesn't know your plan or your dose.

Track the real number over a year

Starter offers end, doses change and refill windows matter. Logging each fill is the easiest way to know what you actually spend. Glidedose shows your cost per dose, monthly spend and when your supply runs out.

Frequently asked questions

How much is Wegovy without insurance?

Through NovoCare Pharmacy, Wegovy pens are $349 a month for 0.25 mg to 2.4 mg and $399 for 7.2 mg. New patients pay $199 for their first two monthly fills of 0.25 mg or 0.5 mg through December 31, 2026. The list price is $1,349.02 a month.

How much is Zepbound without insurance?

LillyDirect lists Zepbound self-pay at $299 a month for 2.5 mg and $399 for 5 mg. Higher doses are $449 if you refill within 45 days under the Zepbound Self Pay Journey Program, otherwise $499 or $699.

Why is the pharmacy price so much higher?

If a pharmacy fills the drug without a manufacturer program or coupon attached, you can be charged close to the list price, which is over $1,000 a month. Ask which price you are getting.

Do self-pay purchases count toward my deductible?

Generally no. Cash purchases through manufacturer programs or TrumpRx go outside your insurance. Check with your plan.

Sources

This page is general cost information, not medical, insurance or financial advice. Prices and program terms change often and eligibility rules apply. Confirm the current price with the manufacturer or your pharmacy, and talk to your prescriber about which medication and dose are right for you.