GLP-1 overdose: what the labels say in the US and Canada

If you think you or someone else took too much: US Poison Help 1-800-222-1222 · Canada 1-844 POISON-X (1-844-764-7669) · emergency 911. Say which product, the strength and when each dose was taken.

Short answer: every US label (section 10, Overdosage) and Canadian product monograph (section 5, Overdose) for Ozempic, Wegovy, Rybelsus, Mounjaro, Zepbound, Saxenda, Victoza and Trulicity says the same core thing: start supportive treatment based on symptoms, and contact poison control or a medical toxicologist. The effects the labels list are severe nausea, severe vomiting (with dehydration risk) and severe hypoglycemia. There is no specific antidote, and because semaglutide and tirzepatide have long half-lives (about 1 week and about 5 days), symptoms may need watching for an extended period. Below is the label-by-label wording, the Canada vs US differences, the FDA's compounded semaglutide alert, and what to note in a GLP-1 tracker.

On this page: US labels · Half-lives · Canada · Compounded semaglutide · Symptoms to report · What to log

US labels: section 10, Overdosage

All eight current US prescribing information documents on DailyMed name the Poison Help line (1-800-222-1222) or a medical toxicologist for overdose management, and all say treatment should be supportive and guided by the patient's signs and symptoms.

Product	What section 10 says	Observation / half-life
Ozempic (semaglutide injection)	Supportive treatment per signs and symptoms; Poison Help or medical toxicologist	Prolonged observation may be needed; half-life about 1 week
Wegovy (semaglutide)	Overdoses reported with other GLP-1 RAs: severe nausea, severe vomiting, severe hypoglycemia. Supportive treatment; Poison Help or medical toxicologist	Prolonged observation may be needed; half-life about 1 week
Rybelsus / Ozempic tablets (oral semaglutide)	Supportive treatment per signs and symptoms; Poison Help or medical toxicologist	Prolonged observation may be needed; half-life about 1 week
Mounjaro (tirzepatide)	Poison Help or medical toxicologist; supportive treatment per signs and symptoms	Observation period may be needed; half-life about 5 days
Zepbound (tirzepatide)	Poison Help or medical toxicologist; supportive treatment per signs and symptoms	Observation period may be needed; half-life about 5 days
Saxenda (liraglutide)	Overdoses reported in trials and post-marketing: severe nausea, severe vomiting, severe hypoglycemia. Poison Help or medical toxicologist; supportive treatment	Half-life about 13 hours (section 12.3)
Victoza (liraglutide)	Overdoses reported in trials and post-marketing: severe nausea, severe vomiting, severe hypoglycemia. Poison Help or medical toxicologist; supportive treatment	Half-life about 13 hours (section 12.3)
Trulicity (dulaglutide)	Overdoses reported in clinical studies: mainly mild or moderate GI events (nausea, vomiting) and non-severe hypoglycemia. Poison Help or medical toxicologist; supportive care with frequent plasma glucose monitoring	Half-life about 5 days (section 12.3)

Wegovy is the only semaglutide label whose section 10 lists specific effects, and it attributes them to overdoses reported with other GLP-1 receptor agonists. The Ozempic and Rybelsus labels describe management only. The FDA's own compounded semaglutide alert quotes the same effects: severe nausea, severe vomiting and severe hypoglycemia.

Why half-life matters in an overdose

Half-life is how long it takes the body to clear half of the drug. The longer it is, the longer overdose effects can last, which is why the semaglutide and tirzepatide labels say prolonged observation may be necessary.

Ingredient	Products	Half-life on the US label	Dosing interval on the label
Semaglutide	Ozempic, Wegovy, Rybelsus	About 1 week	Weekly injection (Ozempic, Wegovy); daily tablet (Rybelsus)
Tirzepatide	Mounjaro, Zepbound	About 5 days	Weekly injection
Dulaglutide	Trulicity	About 5 days	Weekly injection
Liraglutide	Victoza, Saxenda	About 13 hours	Daily injection

For oral semaglutide, the Canadian Rybelsus monograph adds that patients should be instructed that only a single tablet is taken each day.

Canada: product monograph section 5, Overdose

Canadian monographs follow the same supportive-care approach but differ from the US labels in detail. Five of them (Ozempic, Wegovy, Rybelsus, Mounjaro, Zepbound) give Health Canada's toll-free poison number, 1-844 POISON-X (1-844-764-7669); Saxenda, Victoza and Trulicity point to your regional poison control centre.

Product	What the Canadian monograph says	Who to contact
Ozempic	Overdoses reported in clinical trials; most common event nausea; all patients recovered without complications. No specific antidote. Supportive treatment; prolonged observation given half-life of about 1 week.	1-844 POISON-X or regional poison centre
Wegovy	Overdose with semaglutide or other GLP-1 RAs may be associated with severe hypoglycemia, severe nausea and severe vomiting that could lead to dehydration. No specific antidote. Observe for clinical signs; supportive treatment; prolonged observation (half-life about 1 week).	1-844 POISON-X or regional poison centre
Rybelsus	Overdose may be associated with GI disorders (e.g. nausea); all clinical-study patients who reported overdosing recovered without complications. Patients should be told only a single tablet is taken daily. No specific antidote; supportive treatment; prolonged observation.	1-844 POISON-X or regional poison centre
Mounjaro	Potential symptoms could be gastrointestinal (e.g. nausea). Supportive care including frequent blood glucose monitoring; prolonged observation may be necessary given the long half-life.	1-844 POISON-X or regional poison centre
Zepbound	Same wording as Mounjaro: GI symptoms (e.g. nausea), supportive care with frequent blood glucose monitoring, prolonged observation given the long half-life of tirzepatide.	1-844 POISON-X or regional poison centre
Saxenda	Overdoses reported in trials and post-marketing: severe nausea, severe vomiting; severe hypoglycemia observed. Supportive treatment; observe for dehydration and monitor blood glucose.	Regional poison control centre
Victoza	Overdoses reported up to 40 times the recommended maintenance dose; one 10-fold overdose given for 7 months; all recovered without complications. Severe nausea, vomiting and diarrhea; severe hypoglycemia observed. Supportive treatment; observe for dehydration; monitor blood glucose.	Regional poison control centre
Trulicity	Overdoses reported in clinical studies: mainly mild or moderate GI events (nausea, vomiting) and non-severe hypoglycemia. Supportive care including frequent plasma glucose monitoring.	Regional poison control centre

The main Canada vs US differences: the Canadian Ozempic, Wegovy and Rybelsus monographs state plainly that there is no specific antidote; the Canadian Ozempic, Rybelsus and Victoza monographs describe recovery in reported overdose cases; and the Canadian Mounjaro and Zepbound monographs ask for frequent blood glucose monitoring, a point the US tirzepatide labels do not include in section 10. Saxenda and Victoza in both countries ask clinicians to watch for dehydration.

Compounded semaglutide and dosing errors (FDA alert)

On July 26, 2024 the FDA alerted health care providers, compounders and patients that it had received reports of adverse events, some requiring hospitalization, that may be related to overdoses from dosing errors with compounded semaglutide injections. According to the FDA:

Errors came from patients measuring and self-injecting incorrect amounts and from health care providers miscalculating doses.
Many affected patients had vials of compounded semaglutide and little experience with self-injection; confusion between milliliters, milligrams and "units" may have contributed.
Compounded products can come in multiple-dose vials or prefilled syringes, and concentrations vary between compounders, sometimes within one compounder.
FDA-approved Wegovy comes in single-dose pre-filled pens and Ozempic in multiple-dose pre-filled pens; compounded drugs do not undergo FDA premarket review for safety, quality or effectiveness.

The FDA asks patients to talk with their health care provider or compounder about how to measure and give the intended amount. Glidedose does not calculate or suggest doses.

Symptoms worth reporting quickly

Severe or repeated vomiting, or being unable to keep fluids down: dehydration can lead to kidney injury, see the kidney and dehydration warning.
Low blood sugar signs such as shakiness, sweating, confusion, fast heartbeat or drowsiness, especially if you also take insulin or a sulfonylurea; see the hypoglycemia warning.
Severe stomach pain, which the labels also link to pancreatitis and gallbladder problems; see pancreatitis and gallbladder warnings and the severe GI warning.
Fainting, trouble breathing or seizures: call 911.

What to log and tell poison control or your prescriber

The product name, pen or tablet strength, and whether it was a brand pen or a compounded vial.
The date and time of the extra dose and of the dose before it.
Every other diabetes medicine you take, especially insulin or a sulfonylurea.
Symptoms with times: nausea, vomiting, fluids kept down, blood sugar readings if you check them.
The advice you were given about your next scheduled dose, written down exactly. For the label rules on missed doses (not extra ones), see missed GLP-1 dose.

For the other class warnings, see severe GI adverse reactions, low blood sugar, kidney and dehydration, doses per pen and tracking side effects.

Sources

This page summarizes official product labels and FDA communications as general information. It is not medical advice. Do not start, stop or change any medication based on this page. Labels are updated; check the current version for your product. In an emergency call 911.

Frequently asked questions

What happens if you take too much Ozempic, Wegovy or Mounjaro?

The labels describe overdose effects as mainly gastrointestinal: severe nausea and severe vomiting (which can lead to dehydration), and severe hypoglycemia (low blood sugar) on the semaglutide and liraglutide labels. The Mounjaro and Zepbound monographs say potential overdose symptoms could be gastrointestinal (for example nausea) and call for frequent blood glucose monitoring. If you think you or someone else took too much, call Poison Help (US 1-800-222-1222) or Canada 1-844 POISON-X (1-844-764-7669), or 911 if symptoms are severe.

Is there an antidote for a GLP-1 overdose?

No. The Canadian Ozempic, Wegovy and Rybelsus monographs state there is no specific antidote for overdose. Every US label and Canadian monograph says to start appropriate supportive treatment according to the patient's clinical signs and symptoms. That treatment is decided by poison control and medical staff, not by an app or a web page.

Why can GLP-1 overdose symptoms last for days?

Because these drugs stay in the body a long time. US labels give a half-life of about 1 week for semaglutide (Ozempic, Wegovy, Rybelsus) and about 5 days for tirzepatide (Mounjaro, Zepbound); the Trulicity label gives about 5 days for dulaglutide; Victoza and Saxenda give about 13 hours for liraglutide. The semaglutide and tirzepatide labels say a prolonged (or extended) period of observation and treatment may be necessary because of that half-life.

What number do I call for a GLP-1 overdose in the US?

All eight US labels name the Poison Help line, 1-800-222-1222, or a medical toxicologist for overdose management advice. Call 911 for trouble breathing, fainting, confusion, seizures or vomiting so severe you cannot keep fluids down.

What number do I call in Canada?

The Canadian monographs for Ozempic, Wegovy, Rybelsus, Mounjaro and Zepbound give Health Canada's toll-free number, 1-844 POISON-X (1-844-764-7669), or your regional poison control centre. The Saxenda, Victoza and Trulicity monographs say to contact your regional poison control centre. Call 911 in an emergency.

I injected twice by mistake. What should I do?

Glidedose cannot tell you what to do about an extra injection. Contact poison control (US 1-800-222-1222, Canada 1-844-764-7669) or your pharmacist or prescriber, and say which product, when you took it and when you took the previous one. Do not skip or change upcoming doses unless a healthcare professional tells you to. For the label rules on missed (not extra) doses, see the missed-dose guide.

Have people recovered from GLP-1 overdoses in trials?

The labels report recovery in the overdose cases they describe. The Canadian Ozempic monograph says overdoses were reported in clinical trials, the most common event was nausea and all patients recovered without complications. The Canadian Rybelsus monograph says all clinical-study patients who reported overdosing recovered without complications. The Canadian Victoza monograph describes overdoses reported up to 40 times the recommended maintenance dose, including one 10-fold overdose given for 7 months, with all patients recovering; they reported severe nausea, vomiting and diarrhea, and severe hypoglycemia has been observed. Past recovery does not mean an overdose is safe to manage at home.

Why did the FDA warn about compounded semaglutide overdoses?

In July 2024 the FDA said it had received reports of adverse events, some requiring hospitalization, that may be related to overdoses from dosing errors with compounded semaglutide injections. Errors came from patients measuring doses from vials themselves and from providers miscalculating, with confusion between milliliters, milligrams and "units". FDA-approved Wegovy and Ozempic come in pre-filled pens; compounded products are not FDA-reviewed for safety, quality or effectiveness.

Is a GLP-1 overdose more dangerous with insulin or a sulfonylurea?

The labels already warn that GLP-1s used with insulin or an insulin secretagogue (such as a sulfonylurea) raise the risk of hypoglycemia, and severe hypoglycemia is one of the listed overdose effects. The Trulicity label (US and Canada) and the Canadian Mounjaro and Zepbound monographs call for frequent glucose monitoring in an overdose. Tell poison control about every diabetes medicine you take.

What should I note in a GLP-1 tracker after a suspected overdose?

The product and pen or tablet strength, the date and time of each dose (including the extra one), what poison control or your care team told you, and symptoms with times: nausea, vomiting, how much fluid you kept down, blood sugar readings if you check them. Glidedose is a GLP-1 tracker for dates and symptoms; it never suggests a dose.

Missed a GLP-1 dose?
US label windows plus all 8 Canadian monographs: Wegovy 3-day day-change, Victoza restart difference, and a date calculator.GLP-1 low blood sugar warning
Hypoglycemia rates from each label alone, with insulin and with sulfonylureas, plus Canada's driving advice.GLP-1 severe GI adverse reactions warning
Oct 2025 severe GI rates, gastroparesis and ileus wording from all 8 US labels and Canadian monographs.GLP-1 kidney and dehydration warning
Acute kidney injury wording and trial rates from each label, severe GI rates, and Canada's ESRD rules.How many doses are in a GLP-1 pen?
Doses per Ozempic, Wegovy, Mounjaro, Zepbound, Trulicity, Victoza and Saxenda pen, and when to discard it.Tracking GLP-1 side effects
A practical way to log symptoms so your appointments are more useful.