GlidedosePrices checked November 1, 2026 against Canada's Drug Agency (CDA-AMC), published Canadian pharmacy price reports and US self-pay price tables. Canadian amounts in CAD, US amounts in USD.
Zepbound cost in Canada vs the US
Short answer: in Canada, Eli Lilly's submitted price for a 4-dose Zepbound KwikPen is $300 CAD (2.5 or 5 mg), $420 (7.5 or 10 mg) or $540 (12.5 or 15 mg), and Ontario pharmacies charged about $345 to $607 cash in October 2026. In the US the list price is about $1,087 a month, and LillyDirect self-pay is $299, $399 or $449 depending on strength, if you refill on time.
Jump to: Side-by-side prices · US prices and fine print · Canada prices by pharmacy · Public coverage in Canada · CDA-AMC cost-effectiveness · Calculator
Zepbound price: Canada vs US, same 4 weeks
Each row is one four-week supply (4 weekly doses). Conversions use the Bank of Canada rate of 1.3960 CAD per USD on October 30, 2026. "A year" is 13 four-week supplies.
| Price basis | 4 weeks (CAD) | 4 weeks (USD) | Year (CAD) | Year (USD) | Note |
|---|---|---|---|---|---|
| Canada: 2.5 or 5 mg, sponsor submitted price | $300.00 | $214.90 | $3,900 | $2,794 | Per 4-dose KwikPen, before pharmacy markup and fee (CDA-AMC SR0920) |
| Canada: 7.5 or 10 mg, sponsor submitted price | $420.00 | $300.86 | $5,460 | $3,911 | Per 4-dose KwikPen (CDA-AMC SR0920) |
| Canada: 12.5 or 15 mg, sponsor submitted price | $540.00 | $386.82 | $7,020 | $5,029 | Per 4-dose KwikPen (CDA-AMC SR0920) |
| Canada: 5 mg, Rexall Ontario cash | $357.49 | $256.08 | $4,647 | $3,329 | $345 + $12.49 dispensing fee (GLP1Prices, Oct 2026) |
| Canada: 10 mg, Walmart Ontario cash | $458.99 | $328.79 | $5,967 | $4,274 | $449 + $9.99 dispensing fee (GLP1Prices, Oct 2026) |
| Canada: 15 mg, Shoppers Drug Mart Ontario cash | $606.99 | $434.81 | $7,891 | $5,652 | $595 + $11.99 dispensing fee (GLP1Prices, Oct 2026) |
| US: list price | $1,517.45 | $1,087.00 | $19,727 | $14,131 | Per month, before any discount (GLP1Numbers) |
| US: LillyDirect self-pay, 2.5 mg | $417.40 | $299.00 | $5,426 | $3,887 | Vials or KwikPen, same price |
| US: LillyDirect self-pay, 5 mg | $557.00 | $399.00 | $7,241 | $5,187 | Vials or KwikPen, same price |
| US: LillyDirect self-pay, 7.5 to 15 mg, on-time refill | $626.80 | $449.00 | $8,148 | $5,837 | Refilled within 45 days under the Self Pay Journey Program |
| US: LillyDirect, 10 to 15 mg, late refill | $975.80 | $699.00 | $12,685 | $9,087 | Price when the 45-day refill window is missed ($499 at 7.5 mg) |
Arithmetic on published prices, not a pharmacy quote. Submitted prices are what Eli Lilly Canada filed with CDA-AMC; pharmacy prices are from GLP1Prices' Ontario listings; US prices are from the GLP1Numbers self-pay table, which matches LillyDirect. Strengths are shown to match a price to a pen, not as a dosing guide. Real annual totals mix strengths, because dosing starts low and changes on your prescriber's plan.
US: list price vs what people pay
| Situation (US) | Price per month | Fine print |
|---|---|---|
| List price | about $1,087 | Before insurance or discounts |
| LillyDirect self-pay, 2.5 mg | $299 | Valid on-label prescription; insurance not used |
| LillyDirect self-pay, 5 mg | $399 | Same price for vials or KwikPen since February 2026 |
| LillyDirect self-pay, 7.5 to 15 mg | $449 | Requires refilling within 45 days (Zepbound Self Pay Journey Program) |
| Late refill, 7.5 mg / 10 to 15 mg | $499 / $699 | When the 45-day refill window is missed |
| Medicare Part D, weight management | $50 copay | Medicare GLP-1 Bridge for the Zepbound KwikPen, for enrollees who meet the clinical criteria |
LillyDirect orders can be delivered or picked up at a Walmart pharmacy at the same price. Vials need separate syringes and needles. Full US program rules are in US savings programs and GLP-1 cost without insurance.
Canada: cash price by pharmacy (Ontario, October 2026)
| Strength (1 pen, 4 doses) | Pharmacy | Drug price | Dispensing fee | Total |
|---|---|---|---|---|
| 2.5 mg | Pharmasave | $354.00 | not listed | $354.00 before fee |
| 5 mg | Rexall | $345.00 | $12.49 | $357.49 |
| 7.5 mg | Walmart / Rexall / Shoppers Drug Mart | $436.00 / $460.00 / $468.00 | not listed / $12.49 / $11.99 | $436.00* / $472.49 / $479.99 |
| 10 mg | Walmart / Rexall / Loblaws | $449.00 / $460.00 / $558.00 | $9.99 / $12.49 / not listed | $458.99 / $472.49 / $558.00* |
| 12.5 mg | Costco / Walmart / Rexall / Shoppers Drug Mart | $440.00 / $572.00 / $585.00 / $595.00 | not listed / $9.99 / $12.49 / $11.99 | $440.00* / $581.99 / $597.49 / $606.99 |
| 15 mg | Walmart / Rexall / Shoppers Drug Mart | $580.00 / $585.00 / $595.00 | not listed / $12.49 / $11.99 | $580.00* / $597.49 / $606.99 |
* Before the dispensing fee, which was not listed. Source: GLP1Prices Ontario listings (shopper reports and team research, October 2026), cash prices before any manufacturer savings card. Prices differ by province and store; always ask your pharmacy for a quote.
- Pharmacy markup. At 12.5 or 15 mg, Ontario totals of $580 to $607 sit $40 to $67 above the $540 submitted price; the Costco 12.5 mg report of $440 before fee was below it.
- Pens. The Canadian KwikPen is a multi-dose pen holding 4 weekly doses, so one pen is one four-week supply. See doses per pen.
- Tax. Out-of-pocket prescription costs can count toward the CRA medical expense tax credit; see the claim rules and calculator.
Public coverage in Canada: what CDA-AMC recommended
In its 2026 review (SR0920), CDA-AMC found Zepbound did not show acceptable clinical value for the full Health Canada population (BMI 30 or more, or 27 to under 30 with a weight-related condition), but did for adults with a BMI of 27 or more and prediabetes. It recommended reimbursement for that group only, with these conditions:
| Condition | What it says |
|---|---|
| Who | Adults with a BMI of 27 kg/m² or more and prediabetes, with at least 1 self-reported unsuccessful diet attempt |
| Alongside | A reduced-calorie diet and increased physical activity |
| Renewal after year 1 | At least a 5% reduction in total body weight from baseline must be documented |
| After that | Yearly reassessment; the initial response must be maintained |
| Not with | Other GLP-1 receptor agonists |
| Price | A reduction in price |
A recommendation is advice to the public plans, not a listing. Each province and territory decides whether and how to list Zepbound, and private plans set their own rules. The other brands' reviews are compared in Ozempic vs Wegovy vs Zepbound price.
What CDA-AMC found on cost
| Measure (prediabetes population, submitted price) | 5 mg | 10 mg | 15 mg |
|---|---|---|---|
| Cost per QALY gained vs diet and exercise | $77,871 | $97,940 | $123,265 |
| Price cut needed for $50,000 per QALY | 25% to 49% | 25% to 49% | 25% to 49% |
| Price cut needed for $100,000 per QALY | none | none | 1% to 24% |
QALY means quality-adjusted life-year. CDA-AMC put the annual drug cost at $3,913 to $7,044 per patient depending on dose, and the budget impact of covering the prediabetes group at about $2.4 billion over the first 3 years. It called the estimates highly uncertain.
Zepbound cost calculator (CAD or USD)
Arithmetic only, assuming 4 weekly doses per pen or month and 52 doses a year. The default exchange rate is the Bank of Canada rate for October 30, 2026; replace it with today's rate.
Track what each pen really costs
Zepbound's price changes with strength, and in the US with refill timing. Logging each pen, what you paid and what was covered shows your true cost per dose and warns you before a refill window closes.
Frequently asked questions
How much does Zepbound cost in Canada?
Eli Lilly Canada submitted a price of $300 CAD per 4-dose KwikPen for 2.5 or 5 mg, $420 for 7.5 or 10 mg and $540 for 12.5 or 15 mg to Canada's Drug Agency (CDA-AMC). Pharmacy cash prices are higher: in Ontario in October 2026, GLP1Prices listed $345 to $354 before fees for the lower strengths, $436 to $558 for 7.5 or 10 mg and $440 to $606.99 for 12.5 or 15 mg, depending on pharmacy.
How much does Zepbound cost in the US?
The list price is about $1,087 a month. Through LillyDirect self-pay, Zepbound is $299 for 2.5 mg, $399 for 5 mg and $449 for 7.5 to 15 mg if you refill within 45 days; a late refill costs $499 at 7.5 mg or $699 at 10 to 15 mg. Since February 2026 the vial and the 4-dose KwikPen cost the same through LillyDirect.
Is Zepbound cheaper in Canada or the US?
At the starting strengths it is about even: the $300 CAD Canadian submitted price is about $215 USD, but Canadian pharmacy cash was $345 to $357 CAD ($247 to $256 USD) against $299 to $399 USD US self-pay. At 12.5 or 15 mg, Canadian cash of $440 to $607 CAD is about $315 to $435 USD, similar to or below the $449 US self-pay price and well below the $699 late-refill price.
Do provincial drug plans cover Zepbound?
CDA-AMC recommended in 2026 (SR0920) that public plans reimburse Zepbound only for adults with a BMI of 27 or more and prediabetes who have had at least 1 unsuccessful diet attempt, alongside a reduced-calorie diet and more physical activity, with renewal after year 1 only if at least a 5% weight reduction is documented, yearly reassessment, no combination with other GLP-1 drugs, and a price reduction. Each province decides its own listing.
How much does Zepbound cost per year in Canada?
CDA-AMC put the annual cost at the submitted price at $3,913 to $7,044 CAD per patient, depending on dose. At Ontario pharmacy cash prices, 13 four-week pens cost about $4,647 CAD at $357.49 a pen and $7,891 at $606.99.
Is Zepbound the same as Mounjaro in Canada?
Both contain tirzepatide from Eli Lilly and use the same submitted price tiers in Canada ($300, $420, $540 per pen). Mounjaro is the type 2 diabetes brand and Zepbound the weight management brand, and each was reviewed separately by CDA-AMC with different coverage conditions. See the Mounjaro Canada vs US page for that brand.
Does Medicare cover Zepbound?
Medicare Part D enrollees who meet the clinical criteria may qualify for the $50-a-month Medicare GLP-1 Bridge for the Zepbound KwikPen, according to GLP1Numbers' summary of the CMS program. Manufacturer copay savings cards generally exclude government insurance.
Sources
- CDA-AMC, tirzepatide (Zepbound) reimbursement recommendation SR0920: conditions, submitted prices, annual cost, cost-effectiveness and budget impact
- CDA-AMC, tirzepatide (Zepbound) project page
- GLP1Prices: Zepbound prices in Ontario (October 2026)
- GLP1Numbers: LillyDirect and NovoCare self-pay prices and list prices (October 10, 2026)
- Zepbound on LillyDirect (Eli Lilly)
- Zepbound prescribing information (FDA label via DailyMed)
- Bank of Canada daily exchange rates (USD/CAD 1.3960, October 30, 2026)
Prices and program terms change often and eligibility rules apply; confirm with your pharmacy or Eli Lilly. This page is general information, not medical advice, and does not recommend any medication, strength or dose. Talk to your prescriber or pharmacist before starting, stopping or switching a medication.
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